- 117 Medical Behavioral Science Building
Dr. Lile has continued to focus research efforts on the study of cannabis-use disorder. Currently, this work is supported by an R01 to evaluate the voltage-dependent calcium channel ligand pregabalin as a medication for cannabis-use disorder, as determined using innovative outpatient maintenance procedures to determine pharmacotherapy effects on cannabis use in the laboratory and in the natural environment. This year, Dr. Lile published one first author manuscript, one senior author manuscript, one co-authored manuscript, and submitted another co-authored manuscript based on research on cannabis-use disorder. Also of note is that he was invited to present his research on cannabis-use disorder in small group setting that included the Director of the National Institute on Drug Abuse, the President of UK, the UK Vice President for Research, and the Dean of the UK College of Medicine. Another active area of research for Dr. Lile has been the development of pharmacotherapies for the treatment of stimulant-use disorder in collaboration with Drs. Craig Rush and Bill Stoops. Dr. Lile made excellent progress this year on his R01 to develop a translational platform for cocaine medications development in monkeys and humans in collaboration with colleagues at Virginia Commonwealth University. He presented results from this research at a satellite of the College on Problems of Drug Dependence (CPDD) meeting, and published a first author and co-authored manuscript based on this work. A competing renewal application of this project was submitted this year, and will examine the role of 5-HT2 ligands in cocaine choice. He also served as a Co-Investigator on eight R-level awards, and is a Co-Investigator on four additional R-level grants that are under review, in this area. His involvement in stimulant research as a co-investigator resulted in six additional co-authored manuscripts that are either published, in press or under review, and seven conference presentations. A third area of research involvement for Dr. Lile has been the study of the influence of individual differences such as personality factors on vulnerability to drug use in collaboration with Dr. Tom Kelly, which is supported by a P50 Center on Drug Abuse Translation (CDART). His involvement in that center resulted in two co-authored manuscripts (one in press and one under review). The renewal application for that center was submitted this year, and included Dr. Lile as an MPI on a project that will examine the influence of drug effect expectancies and social environment on drug use vulnerability. Worth noting is that this year Dr. Lile was invited to present his research at Wake Forest University and Virginia Commonwealth University, as well as to visiting Brown Scholars at a symposium at UK. In addition to these research activities, Dr. Lile has been engaged in mentoring early career scientists. More specifically, he has mentored Dr. Michael Wesley, a research title series assistant professor, on incorporating clinical pharmacology techniques into his neuroimaging and electrical brain stimulation research. Together, Dr. Wesley and Dr. Lile published one manuscript, and recently submitted another, in 2016. Dr. Lile is serving as the mentor for Dr. Wesley’s pending K01 application and funded CCTS pilot award that aim to determine the ability of transcranial direct current stimulation to attenuate the intoxicating effects of THC, the primary active constituent of cannabis. They also formed a team of inventors that successfully competed for financial support to develop a biofeedback and brain entrainment device that, if viable, will be the basis for the foundation of a biotech company. Dr. Lile is serving as a co-primary mentor for Drs. Craig Beavers and Kevin Hatton, two Ph.D. candidates in the UK Clinical and Translational Science program. He is also serving as co-mentor for two post-doctoral fellows, Drs. Anna Reynolds and Joe Alcorn, as a doctoral dissertation committee member for Ginny Weiss, Arit Harvanko, and Justin Strickland, who are students in the Psychology graduate program, and as a training faculty member on two NIDA T32 training grants. Formal academic instruction included acting as the co-director of BSC 731, Methods and Technologies in Clinical and Translational Science, and providing guest lectures for a Psychology course and a Pharmacy course. Dr. Lile has continued to provide service to the academic and research community. In 2016, he was a member of the CPDD Long Range Planning Committee (ongoing) and the Human Research Committee (3-year term ended this year). He reviewed 7 manuscripts, and served as a grant reviewer for the internal pilot research program supported by the UK Office of the Vice President for Research and for the Oak Ridge Associated Universities Ralph E. Poe Junior Faculty Awards. Lastly, he has continued his service as a regular member of the University of Kentucky Institutional Review Board.