The Neurobehavioral Systems Lab (NSL) is a hub for innovative trans-disciplinary work in the University of Kentucky (UK) College of Medicine (COM). The NSL integrates multimodal neuroimaging, intervention and computational techniques in its approach. Neuroimaging techniques include electroencephalogram (EEG) and various magnetic resonance (MR)-based protocols examining the biology and physiology of neural networks. These techniques include standard MRI procedures to isolate volume and density information for nodal regions of interest (ROIs), functional MRI (fMRI) to isolate energy utilization of ROIs, MR spectroscopy (MRS) to isolate the neurochemical activity within ROIs and diffusion tensor imaging (DTI) to isolate the pathway integrity between ROIs. Intervention techniques include acute and maintenance drug administration to intervene at a microscopic level on neurotransmitter function and non-invasive brain stimulation to intervene at a macroscopic level on neural network function. Computational techniques include mass-univariate and multivariate statistical approaches, including statistical parametric mapping using graph theory and general linear modeling, as well as supervised machine learning for pattern recognition and prediction in high-dimensional data.